Integration of Mouse Phenome Data Resources

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- 1 - Integration of Mouse Phenome Data Resources

* The Mouse Phenotype Database Integration Consortium currently comprises: John M. Hancock, Niels C. Adams, Vassilis Aidinis, Andrew Blake, Judith A. Blake, Molly Bogue, Steve D.M. Brown, Elissa Chesler, Duncan Davidson, Christopher Duran, Janan T. Eppig, Valérie Gailus-Durner, Hilary Gates, Georgios V. Gkoutos, Simon Greenaway, Martin Hrabé de Angelis, George Kollias, Sophie Leblanc, Kirsty Le...

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The Mouse Phenome Project was launched a decade ago to complement mouse genome sequencing efforts by promoting new phenotyping initiatives under standardized conditions and collecting the data in a central public database, the Mouse Phenome Database (MPD; http://phenome.jax.org). MPD houses a wealth of strain characteristics data to facilitate the use of the laboratory mouse in translational re...

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Mice have been used as a genetically-modifiable model animal of human disease in various biomedical research field. Mouse mutant resources is now on the way of expanding by the collaborative production of knockout mouse for all genes under the umbrella of the International Knockout Mouse Consortium (IKMC) [1]. The next major challenge is, the comprehensive and systematic phenotyping of these re...

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Mouse Phenome Database

The Mouse Phenome Database (MPD; phenome.jax.org) was launched in 2001 as the data coordination center for the international Mouse Phenome Project. MPD integrates quantitative phenotype, gene expression and genotype data into a common annotated framework to facilitate query and analysis. MPD contains >3500 phenotype measurements or traits relevant to human health, including cancer, aging, cardi...

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Understanding the source of genetic variation in aging and using this variation to define the molecular mechanisms of healthy aging require deep and broad quantification of a host of physiological, morphological, and behavioral endpoints. The murine model is a powerful system in which to understand the relations across age-related phenotypes and to identify research models with variation in lif...

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ژورنال

عنوان ژورنال: Mammalian Genome

سال: 2008

ISSN: 0938-8990,1432-1777

DOI: 10.1007/s00335-008-9099-8